Napoli Pisa prediction 2025-09-22

Napoli vs Pisa prediction: ITALY: Serie A betting tips on match 2025-09-21 18:45.
[p]After starting their Serie A title defence in perfect fashion, Napoli will look to bounce back from disappointment in Europe when they host newly-promoted Pisa.[/p]

[p]Match News and Current Form[/p]

[p]Napoli’s defence of the Scudetto has been seamless thus far, winning all three of their games in the league, but some of the confidence generated from that was undone by a 2-0 defeat in UEFA Champions League against Manchester City on Thursday. Playing for well over an hour with ten men undoubtedly contributed to that result, so Antonio Conte’s men will look to move on here and continue what is the longest unbeaten streak in Europe’s top-five leagues, as they’ve gone 15 Serie A matches without a defeat (W10, D5).[/p]

[p]Pisa’s 34-year wait for a Serie A victory continues after their 1-0 defeat to Udinese last time out, which saw Alberto Gilardino’s men fail to score for a second successive league match. The fixture schedule has hardly been kind to Pisa with this a third game from four in the league against sides who finished in the European places last term, yet things aren’t about to get any easier as five of their next six league fixtures are against sides who finished in Serie A’s top half last season. This is arguably the toughest of them all for Pisa, who’ve never won against the reigning champions in Serie A (D4, L10).[/p]

[p]Head-to-Head History[/p]

[p]This will be the first competitive meeting between these sides since a 2007 Coppa Italia tie which Napoli won 3-1. The Partenopei have won six of the 14 previous Serie A H2Hs (D5, L3).[/p]

[p]Hot Stats and Streaks[/p]

[p]Napoli are unbeaten in 12 Serie A home games (W9, D3), keeping six clean sheets in that time.[/p]

[p]Napoli have opened the scoring in 15 of their last 20 home league matches.[/p]

[p]Only one of Pisa’s last five away competitive matches produced over 2.5 goals.[/p]

[p]Pisa are the only Serie A side yet to score after the break.[/p]

[p]Key Players to Watch and Missing Players[/p]

[p]Having been substituted early in midweek, Napoli’s Kevin De Bruyne will be keen to build on scoring twice in his opening three Serie A matches, and each of his last nine club goals came in victories. Pisa’s Stefano Moreo has broken the deadlock in four of his last six scoring appearances, despite eight of his last ten goals arriving after the break.[/p]

[p]Amir Rrahmani remains sidelined for Napoli, while Juan Cuadrado will miss this one for Pisa. [/p]

[p]For all the latest team news, please check the Flashscore match centre.[/p]

[p]Betting Analysis[/p]

[p]Given the visitors’ attacking troubles and Napoli’s strong home performances, betting on Napoli winning with a clean sheet could be a smart move.[/p]

[p][i]Author: Tomáš Vlasák[/i][/p]